Step 1. Target Identification to Validation

  1. Naramura, M., Natarajan, A.* “Mouse pancreatic tumor model independent of tumor suppressor gene inactivation” Pancreas, 2018, 47(5), e27-29. PMCID: PMC5926800.

  2. Napoleon, J. V., Sagar, S., Kubica, S. P., Boghean, L., Kour, S., King, H. M., Sonawane, Y. A., Crawford, A. J., Gautam, N., Kizhake, S., Bialk, P. A., Kmiec, E., Mallareddy, J. R., Patil, P., Rana, S., Singh, S., Prahlad, J., Grandgenett, P.M., Borgstahl, G. E. O., Ghosal, G., Alnouti, Y., Hollingsworth, M.A., Radhakrishnan, P., Natarajan, A.* “Small molecule IKKβ activation modulator (IKAM) targets MAP3K1 and inhibits pancreatic tumor growth” Proc. Natl. Acad. Sci. USA 2022, 119(18):e2115071119 PMCID: PMC9170026.


2. Assay Development and Screening