Peer-reviewed Publications

  1. Wallin, S., Pandithar, S., Singh, S., Kumar, S., Natarajan, A. Borgstahl, G. E. O., Woods, N. T. “Surveying the proteome-wide landscape of Mitoxantrone and examining drug-sensitivity in BRCA1-deficient ovarian cancer using quantitative proteomics” Proteomes 2025, 13(4), 61. PMCID: PMC12641731.

  2. Boghean, L., Singh, S., Mangalparthi, K. K., Kizhake, S., Umeta, L., Wishka, D., Grothaus, P., Pandey, A., Natarajan, A.* “A selective MAP3K1 inhibitor facilitates discovery of NPM1 as a member of the network” Molecules 2025, 30(9), 2001. PMCID: PMC12073402.

  3. Mallareddy, J. R., Yang, L., Lin, W-H., Feathers, R., Ayers-Ringler, J., Tolosa, E., Kizhake, A. G., Kizhake, S., Kubica, S. P., Boghean, L., Alvarez, M. J., Naldrett, M. J., Singh, S., Rana, S., Zahid, M., Shaefer-Klein, J., Roden, A., Kosari, F., Anastasiadis, P. Z., Borad, M., Natarajan, A*., Mansfield, A. S. “Fluorescence based live cell imaging identifies exon 14 skipped hepatocyte growth factor receptor (MET) degraders” RSC Adv. 2025, 15, 10419-25. PMCID: PMC11967169.

  4. Azadmanesh, J., Slobodnik, K., Struble, L. R., Lovelace, J. J., Cone, E. A., Dasgupta, M., Lutz, W. E., Kumar, S., Natarajan, A., Coates, L., Weiss, K. L., Myles, A. A. D., Kroll, T., Borstahl, G. E. O. “The role of Tyr34 in proton coupled electron transfer and product inhibition of manganese superoxide dismutase” Nat. Commun. 2025, 16, 1887. PMCID: PMC11846855.

  5. Tolosa, E. J., Yang, L., Ayers-Ringler, J., Suzuki, S., Mallareddy, J. R., Schaefer-Klein, J., Borad, M., Kosari, M., Natarajan, A., Mansfield, A. S. “Proteolysis targeting chimera (PROTAC)-driven antibody internalization of oncogenic cell surface receptors” Commun. Biol. 2024, 7, 1719, 1-10 PMCID: PMC11688428.

  6. Schmitz, E., Ridout, A., Smith, A. L., Eiken, A. P., Skupa, S. A., Drengler, E. M., Singh, S., Rana, S., Natarajan, A., El-Gamal, D. “Immunogenic Cell Death Traits Emitted from Chronic Lymphocytic Leukemia Cells Following Treatment with a Novel Anti-Cancer Agent, SpiD3” Biomedicines 2024, 12, 2857, 1-17 PMCID: PMC11673838.

  7. Eiken, A. P., Schmitz, E., Drengler, E. M., Smith, A. L., Skupa, S. A., Mohan, K., Rana, S., Singh, S., Mallareddy, J. R., Mathew, G., Natarajan, A., El-Gamal, D. “The novel anti-cancer agent, SpiD3, is cytotoxic in CLL cells resistant to Ibrutinib or Venetoclax” Hemato 2024, 5, 321-340. PMCID: PMC11500768.

  8. Qiao, F., Binkowski, T. A., Broughan, I., Chen, W., Natarajan, A., Schiltz, G. A., Scheidt, K. A., Anderson, W. F., Bergan, R. “Protein Structure Inspired Discovery of a Novel Inducer of Anoikis in Human Melanoma” Cancers 2024, 16, 3177, 1-24 PMCID: PMC11429909

  9. Mukthapuram, P. R. Natarajan, A.* “Domino reactions enable Zn-mediated direct synthesis of spiro-fused 2-oxindole-α-methylene-γ-butyrolactones/lactams from isatin derivatives and 2-(bromomethyl)acrylates” Molecules 2024, 29(15), 3612. PMCID: PMC11314261

  10. Mullen, N. J., Shukla, S. K., Thakur, R., Kollala, S. S. Wang, D., Chaika, N., Labreck, D. A., Mallareddy, J. R., Price, D. H., Natarajan, A., Mehla, K., Sykes, D. B., Hollingsworth, M. A., Singh, P. K. “DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation” eLife 2024, 12:RP87292. PMCID: PMC11230267.

  11. Vorderbruggen, M., Velázquez-Martínez, C. A., Natarajan, A., Karpf, A. R. “PROTACs in ovarian cancer: Current advancements and future perspectives” Int. J. Mol. Sci. 2024, 25(10), 5067. PMCID: PMC11121112.

  12. Eiken, A. P., Smith, A. L., Skupa, S. A., Schmitz, E., Rana, S., Singh, S., Kumar, S., Mallareddy, J. R., de Cubas, A. A., Krishna, A., Kalluchi, A., Rowley, M. J., D’Angelo, C. R., Lunning, M. A., Bociek, R. G., Vose, J. M., Natarajan, A., El-Gamal, D. “Novel spirocyclic dimer, SpiD3, targets chronic lymphocytic leukemia survival pathways with potent preclinical effects” Cancer Res. Commun. 2024, 4(5), 1328-1343. PMCID: PMC11110724.

  13. Bhat, A. Q., Mohapatra, B. C., Luan, H., Mushtaq, I., Chakraborty, S., Kumar, S., Wangbin, W., Dutta, S., Stork, M. D., Schott, M., Meza, J. L., Lele, S. M., Ming-Fong, L., Cook, L. M., Corey, E., Morrissey, C., Coulter, D. W., Rowley, M. J., Natarajan, A., Datta, K., Band, V., Band, H. “GD2 and its biosynthetic enzyme GD3 synthase promote tumorigenesis in prostate cancer by regulating cancer stem cell behavior” Scientific Reports 2024, 14(1), 13523. PMCID: PMC10055271.

  14. Murthy, D., Attri, K. S., Shukla, S. K., Thakur, R., Chaika, N. V., He, C., Wang, D., jha, K., Dasgupta, A., King, R. J., Multer, S., Souchek, J., Gebregiworgis, T., Rai, V., Patel, R., Hu, T., Rana, S., Kollala, S. S., Pacheco, C., Grandgenett, P. M., Yu, F., Kumar, V., Lazengy, A., Black, A. R., Ulhannan, S., Jain, A., Edil, B., Klinkebiel, D., Powers, R., Natarajan, A., Hollingsworth, M. A., Mehla, K., Ly, Q., Chaudhary, S., Hwang, R. F., Wellen, K., Singh, P. K. “Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2-SP1-SAT1 axis” Nat. Cell Biol. 2024, 26(4), 613-627. PMCID: PMC11021164.

  15. Wallin, S., Singh, S., Borgstahl, GEO., Natarajan, A.* “Design, synthesis and evaluation of a mitoxantrone probe (MXP) for biological studies” Bioorg. Med. Chem. Lett. 2023, 94: 1294645. PMCID: PMC10528225.

  16. Pathirage, R., Favrot, L., Petit, C., Yamsek, M., Singh, S., Mallareddy, J. R., Rana, S., Natarajan, A., Ronning, D. R. “Mycobacterium tuberculosis CitA activity is modulated by cysteine oxidation and pyruvate binding” RSC Med. Chem. 2023, 14(5), 921-933. PMCID: PMC10211323.

  17. Umfress, A., Chakraborti, A., Priya, S., Adams, R., Epstein, D., Massicano, A., Sorace, A., Singh, S., Hossian, I., Anrabi, S., Crossman, D., Kumar, N., Mukhtar, S., Simpson, C., Stokes, M., Widerhold, T., Rosen, C., Luo, H., Lu, H., Natarajan, A., Bibb, J. A. “Cdk5 mediates rotational force-induced brain injury” Sci. Rep. 2023, 13(1), 3394 doi.org/10.1038/s41598-023-29322-4 PMCID: PMC9974974.

  18. Fatima, I., Uppada, J. P., Chhonker, Y. S., Gowrikumar, S., Barman, S., Roy, S., Tolentino, K. T., Palermo, N., Natarajan, A., Beaucham, D. R., Vecchio, A., Murry, D. J., Singh, A. B., Hopkins, C. R., Dhawan, P. “Identification and characterization of a first-generation inhibitor of claudin-1 in colon cancer progression and metastasis” Biomed. Pharmacother. 2023, 159, 114255 doi.org/10.1016/j.biopha.2023.114255. (open access).

  19. Gupta, P., Strange, K., Telange, R., Guo, A., Hatch, H., Sobh, A., Elie, J., Carter, A. M., Totenhagen, J., Tan, C., Sonawane, Y. A., Neuzil, J., Natarajan, A., Ovens, A. J., Oakhill, J. S., Wiederhold, T., Pacak, K., Ghayee, H. K., Meijer, L., Reddy, S., Bibb, J. A. “Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer” Cell Rep. 2022, 40(7):111218 doi: 10.1016/j.celrep.2022.111218. PMCID: PMC9822535.

  20. Harris, R., Yang, M., Schmidt, C., Royet, C., Singh, S., Natarajan, A., Morris, A., Frezza, C., Laman, H. “Fbxo7 promotes Cdk6 activity to inhibit PFKP and glycolysis in T cells.” J. Cell Biol. 2022, 221(7):e202203095 doi: 10.1083/jcb.202203095 PMCID: PMC9178409.

  21. Umfress, A., Singh, S., Ryan, K. J., Chakraborti, A., Plattner, F., Sonawane, Y., Mallareddy, J. R., Acosta, E. P., Natarajan, A., Bibb, J. A. “Systemic administration of a brain permeable Cdk5 inhibitor improves stress-response behavior” Front. Pharmacol. 2022, 13:863762. doi: 10.3389/fphar.2022.863762 PMCID: PMC9134315.

  22. Napoleon, J. V., Sagar, S., Kubica, S. P., Boghean, L., Kour, S., King, H. M., Sonawane, Y. A., Crawford, A. J., Gautam, N., Kizhake, S., Bialk, P. A., Kmiec, E., Mallareddy, J. R., Patil, P., Rana, S., Singh, S., Prahlad, J., Grandgenett, P.M., Borgstahl, G. E. O., Ghosal, G., Alnouti, Y., Hollingsworth, M.A., Radhakrishnan, P., Natarajan, A.* “Small molecule IKKβ activation modulator (IKAM) targets MAP3K1 and inhibits pancreatic tumor growth” Proc. Natl. Acad. Sci. USA 2022, 119(18):e2115071119 PMCID: PMC9170026.

  23. Kour, S., Rana, S., Kubica, S. P., Kizhake, S., Ahmad, M., Muñoz-Trujillo, C., Klinkebiel, D., Singh, S., Mallareddy, J. R., Chandra, S., Woods, N. T., Karpf, A. R., Natarajan, A.* “Spirocyclic dimer SpiD7 activates the unfolded protein response to selectively inhibit growth and induce apoptosis of cancer cells” J. Biol. Chem. 2022, 298(5):101890. PMCID: PMC9062249.

  24. Rana, S., Kour, S., Kizhake, S., King, H. M., Klinkebiel, D., Mallareddy, J. R., Case, A. J., Huxford, T., Natarajan, A.* “Dimers of isatin derived α-methylene-γ-butyrolactone as potent anti-cancer agents” Bioorg. Med. Chem. Lett. 2022, 65:128713. PMCID: PMC9037195.

  25. Pramanik, S., Chen, Y., Song, H., Khutsishvili, I., Marky, L. A., Ray, S., Natarajan, A., Singh, P., Bhakat, K. K. “The Human AP-endonuclease 1 (APE1) is a DNA G-quadruplex Structure Binding Protein and Regulates KRAS Expression in Pancreatic Ductal Adenocarcinoma Cells” Nucleic Acids Res. 2022, 50(6):3394-3412. PMCID: PMC8990529.

  26. Kour, S., Rana, S., Kizhake, S., Lagundžin, D., Klinkebiel, D., Mallareddy, J. R., Huxford, T., Woods, N. T., Natarajan, A.* “Stapling proteins in the RELA complex inhibits TNFa-induced nuclear translocation of RELA” RSC Chem Biol. 2022, 3, 32-36. PMCID: PMC8729175.

  27. Mallareddy, J. R., Singh, S., Boghean, L., Natarajan, A.* “Selective CDK9 degradation using a PROTAC strategy” Future Med. Chem., 2022, 14 (3), 131-134. PMID: 34814708.

  28. Yin, L., Zeng, Y., Chen, Y., Wang, T-L., Rodabaugh, K. J., Yu, F., Natarajan, A., Karpf, A. R., Dong, J. “Protein kinase RNA-activated controls mitotic progression and determines paclitaxel chemosensitivity through B-cell lymphoma 2 in ovarian cancer” Oncogene, 2021, 40(50), 6772-6785. PMCID: PMC8688329.

  29. Rana, S., Mallareddy, J. R., Singh, S., Boghean, L., Natarajan, A.* “Inhibitors, PROTACs and Molecular Glues as Diverse Therapeutic Modalities to Target Cyclin-Dependent Kinase” Cancers 2021, 13(9), 5506. (Invited). PMCID: PMC8583118.

  30. Sagar, S., Singh, S., Mallareddy, J. R., Sonawane, Y. A., Napoleon, J. V., Rana, S., Contreras, J. I., Rajesh, C., Ezell, E. L., Kizhake, S., Garrison, J. C., Radhakrishnan, P., Natarajan, A.* “Structure activity relationship (SAR) study identifies a quinoxaline urea analog that modulates IKKβ phosphorylation for pancreatic cancer therapy” Eur. J. Med. Chem. 2021, 222(113579) 1-15. PMCID: PMC8373685.

  31. King, H. M., Rana, S., Kubica, S. P., Mallareddy, J. R., Kizhake, S., Ezell, E. L., Zahid, M., Naldrett, M. J., Alvarez, S., Law, H. C-H., Woods, N. T., Natarajan, A.* “Aminopyrazole based CDK9 PROTAC sensitizes pancreatic cancer cells to Venetoclax” Bioorg. Med. Chem. Lett. 2021, 43(128061) 1-5 PMCID: PMC8187316.

  32. Kumar, B., Ahmad, R., Sharma, S., Gowrikumar, S., Primeaux, M., Rana, S., Natarajan, A., Oupicky, D., Hopkins, C. R., Dhawan, P., Singh, A. B. “PIK3C3 inhibition promotes sensitivity to colon cancer therapy by inhibiting cancer stem cells” Cancers 2021, 13(9), 2168. PMCID: PMC8124755.

  33. Napoleon, J. V., Singh, S., Rana, S., Bendjennat, M., Kumar, V., Kizhake, S., Palermo, N. Y., Ouellette, M. M., Huxford, T., Natarajan, A.* “Small molecule binding to inhibitor of nuclear factor kappa-B kinase subunit beta in an ATP non-competitive manner" Chem. Commun., 2021, 57(38), 4678-81. PMCID: PMC8162871.

  34. Rana, S. and Natarajan, A.* “Small molecule induced polymerization of BCL6 facilitates SIAH1 mediated degradation” (invited) Signal Transduct. Target Ther., 2021, 6(1), 142. PMCID: PMC8016958.

  35. Al-Mugotir, M., Lovelace, J. J., George, J., Bessho, M., Pal, D., Struble, L., Kolar, C., Rana, S., Natarajan, A., Bessho, T., Borgstahl, G. E. O. “Selective killing of homologous recombination-deficient cancer cell lines by inhibitors of the RPA-RAD52 protein-protein interaction” PLoS One. 2021, 16(3), e024941. PMCID: PMC8009417.

  36. Rana, S., Kour, S., Sonawane, Y. A., Robb, C. M., Contreras, J, I., Kizhake, S., Zahid, M., Karpf, A. R., Natarajan, A.* “Symbiotic Prodrugs (SymProDs) Dual Targeting of NFkappaB and CDK” Chem. Biol. Drug Des. 2020, 96, 773. PMCID: PMC8022330.

  37. Tom, E., Mushtaq, I., Mohapatra, B., Luan, H., Bhat, A., Zutshi, N., Chakraborty, S., Islam, N., Arya, P., Bielecki, T., Iseka, F., Bhattacharyya, S., Cypher, L., Goetz, B., Negi, S., Storck, M., Rana, S., Barnekow, A., Singh, P., Ying, G., Guda, C., Natarajan, A., Band, V., Band, H. “EHD1 and RUSC2 control basal EGFR cell surface expression and recycling” Mol. Cell. Biol. 2020, 40(7), e00434-19. PMCID: PMC7076251.

  38. Ahmad, A., Boulton, S., Shao, H., Akimoto, M., Natarajan, A., Cheng, X., Melacini, G. “Recent advances in EPAC-targeted therapies: A biophysical perspective” Cells 2019, 8, 1462. PMCID: PMC6912387.

  39. Nowialis, P., Lopusna, K., Opavska, J., Haney, S. L., Abraham, A., Sheng, P., Riva, A., Natarajan, A., Guryanova, O., Simpson, M., Hlady, R., Xie, M., Opavsky, R. “Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions” Nat. Commun. 2019, 10, 4374. PMCID: PMC6763448.

  40. Zheng, X-F., Acharya, S., Choe, K. N., Nikhil, K., Adelmant, G. O., Satapathy, S. R., Sharma, S., Viccaro, S., Rana, S., Natarajan, A., Sicinski, P., Marto, J. A., Shah, K., Chowdhury, D. “A mitotic CDK5-PP4 phospho-signaling cascade drives 53BP1 for DNA repair in G1” Nat. Commun. 2019, 10, 4252. PMCID: PMC6751209.

  41. Kour, S., Rana, S., Contreras, J. I., King, H. M., Robb, C. M., Sonawane, Y. A., Bendjennat, M., Crawford, A. J., Carter, B., Kizhake, S., Luo, X., Hollingsworth, M. A., Natarajan, A.* “CDK5 inhibitor downregulates Mcl-1 and sensitizes pancreatic cancer cell lines to Navitoclax” Mol. Pharm. 2019, 19, 419-429. PMCID: PMC6726458.

  42. Rana, S., Bendjennat, M., Kour, S., King, H., Kizhake, S., Zahid, M., Natarajan, A.* “Selective degradation of CDK6 by a palbociclib based PROTAC” Bioorg. Med. Chem. Lett. 2019, 29, 1375-1379. PMCID: PMC6487213.

  43. Al-Mugotir, M., Kolar, C., Vance, K., Kelly, D. L., Natarajan, A., Borgstahl, G. E. O. “A simple fluorescent assay for the discovery of protein-protein interaction inhibitors” Anal. Biochem. 2019, 569, 46-52. PMCID: PMC7968734.

  44. Rana, S., Sonawane, Y. A., Taylor, M. A., Kizhake, S., Zahid, M., Natarajan, A.* “Synthesis of aminopyrazole analogs and their evaluation as CDK inhibitors for cancer therapy” Bioorg. Med. Chem. Lett. 2018, 28, 3736-3740. PMCID: PMC6295223.

  45. Contreras, J. I., Robb, C. M., King, H. M., Baxter, J., Crawford, A. J., Kour, S., Kizhake, S., Rana, S., Sonawane, Y. A., Luo, X., Natarajan, A.* “Chemical genetic screens identify kinase inhibitor combinations that target anti-apoptotic proteins for cancer therapy” ACS Chem. Biol. 2018, 13, 1148-1152. PMCID: PMC6119178.

  46. Priebe, A., Hunke, M., Tonello, R., Sonawane, Y. A., Berta, T., Natarajan A., Bhuvanesh, N., Pattabiraman, M., Chandra, S. “Ferulic acid dimer as a non-opioid therapeutic for acute pain” J. Pain Res. 2018, 11, 1075-1085. PMCID: PMC5997134.

  47. Naramura, M., Natarajan, A.* “Mouse pancreatic tumor model independent of tumor suppressor gene inactivation” Pancreas, 2018, 47(5), e27-29. PMCID: PMC5926800.

  48. Robb, C. M., Kour, S., Contreras, J. I., Agarwal, E., Carter, B., Rana, S., Sonawane, Y. A., Neilsen, B., Taylor, M. A., Kizhake, S., Thakare, R., Chowdhury, S., Wang, J., Black, J., Hollingsworth, M. A., Brattain, M., Natarajan, A.* “Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy" Oncotarget, 2018, 9, 5216-5232. PMCID: PMC5797045.

  49. Sonawane, Y. A., Zhu, Y., Garrison, G., Ezell, E., Zahid, M., Cheng, X., Natarajan, A.* “Structure activity relationship studies with tetrahydroquinoline analogs as EPAC inhibitors" ACS Med. Chem. Lett., 2017, 8, 1183-1187. PMCID: PMC5774307.

  50. Bhattacharya, D., Svechkarev, D., Souchek, J. J., Hill, T. K., Taylor, M. A., Natarajan, A., Mohs, A. M. “Impact of structurally modifying hyaluronic acid on CD44 interaction” J. Mater. Chem. B. 2017, 5, 8183-8192. PMCID: PMC5773055.

  51. Abid, M., Sonawane, Y. A., Contreras, J. I., Rana, S., Natarajan, A.* “Recent advances in cancer drug development: Targeting induced myeloid cell leukemia-1 (Mcl-1) differentiation protein” (Invited) Curr. Med. Chem. 2017, 24, 1-27. PMID: PMC28901269.

  52. Yefidoff-Freedman, R., Jing, F., Yan, L., Zhang, Q., DosSantos, G., Rodrigo, R., Rana, S., Contreras, J. I., Sahoo, R., Wan, D., Yang, J., Dias-Teixeira, K., Morisseau, C., Du, R., Halperin, J., Hammock, B., Natarajan, A., Wang, P., H., Chorev, M., Aktas, B. “Development of 1-((1,4-trans)-4-aryloxycyclohexyl)-3-arylurea Activators of the Heme Regulated Inhibitor as Selective Activators of Eukaryotic Translation Initiation Factor 2 Alpha (eIF2α) Phosphorylation Arm of the Integrated Endoplasmic Reticulum Stress Response” J. Med. Chem. 2017, 60, 5392-406. PMCID: PMC5567831.

  53. Robb, C. M., Contreras, J. I., Kour, S., Taylor, M. A., Abid, M., Sonawane, Y. A., Zahid, M., Murry, D. J., Natarajan, A.,* Rana, S. “Chemically induced degradation of CDK9 by a proteolysis targeting chimera (PROTAC)" Chem. Commun., 2017, 53, 7577-80. PMCID: PMC5555382.

  54. Arnst, J. L., Hein, A. L., Taylor, M. A., Palermo, N. Y., Contreras, J. I., Sonawane, Y. A., Wahl, A. O., Ouellette, M. M., Natarajan, A.,* Yan, Y. “Discovery and characterization of small molecule Rac1 inhibitors" Oncotarget, 2017, 8, 34586-600. PMCID: PMC5470993.

  55. Roychoudhury, S., Nath, S., Song, H., Hegde, M., Bello, L., Mantha, A., Sengupta, S., Natarajan, A., Bhakat, K. K. “A novel regulatory role of acetylation of AP-endonuclease 1 (APE1) in DNA damage repair in mammalian cells” Mol. Cell. Biol. 2017, 37, 401-416. PMCID: PMC5335514.

  56. You, W., Huang, T., Kizhake, S., Natarajan, A., Chang, C. “Characterization of promiscuous binding of phosphor ligands to breast-cancer-gene 1 (BRCA1) C-terminal (BRCT): Molecular dynamics, free energy, entropy and inhibitor design” PLoS Comput. Biol. 2016, 12(8):e1005057. PMCID: PMC4999267.

  57. Sonawane, Y., Taylor, M. A., Napolean, J. V., Rana, S., Contreras, J. I., Natarajan, A.* “Cyclin dependent kinase 9 inhibitors for cancer therapy” (invited) J. Med. Chem. 2016, 59, 8667-64. PMCID: PMC5636177.

  58. Hein, A. L., Post, C. M., Sheinin, Y. M., Lakshmanan, I., Natarajan, A., Enke, C. A., Batra, S. K., Ouellette, M. M., Yan, Y. “RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment" Oncogene, 2016, 35(49), 6319-29. PMCID: PMC5112160.

  59. Rana, S., Blowers, E. B., Tebbe, C., Contreras, J. I., Radhakrishnan, P., Kizhake, S., Zhou, T., Rajule, R. N., Arnst, J. L., Munkarah, A., Rattan, R., Natarajan, A.* “Isatin derived spirocyclic analogs with α-methylene-γ-butyrolactone as anticancer agents: A structure activity relationship study” J. Med. Chem. 2016, 59, 5121-27. PMCID: PMC5273401.

  60. Maroni, D., Rana, S., Mukhopadhyay, C., Natarajan, A., Naramura, M. “A quinoxaline urea analog uncouples inflammatory and pro-survival functions of IKKβ” Immunol. Lett. 2015, 168, 319-24. PMCID: PMC4688189.

  61. Mundra, V., Peng, Y., Rana, S., Natarajan, A., Mahato, R. I. “Micellar formulation of indocyanine green for phototherapy of melanoma” J. Control Release 2015, 220, 130-40. PMID: 26482083.

  62. Gautam, N., Thakare, R., Rana, S., Natarajan, A., Alnouti, Y. “Irreversible binding of an anticancer compound (BI-94) to plasma proteins” Xenobiotica 2015, 45, 858-73. PMCID: PMC4553108

  63. Rana, S., Blowers, E. B., Natarajan, A.* “Small molecule adenosine 5’-monophosphate activated protein kinase (AMPK) modulators and human diseases” (invited) J. Med. Chem. 2015, 58, 2-29. PMCID: PMC4864506

  64. Bailey, T. A., Luan, H., Tom, E., Bielecki, T. A., Mohapatra, B., Ahmad, G., George, M., Kelly D. L., Natarajan, A. Raja, S. M., Band, V., Band, H. “A kinase inhibitor screen reveals PKC-dependent endocytic recycling of ErbB2 in breast cancer cells” J. Biol. Chem. 2014, 289, 30443-30458. PMCID: PMC4215227

  65. Chen, T., Takrouri, K., Hee-Hwang S. H., Rana, S., Yefidoff-Freedman, R., Halperin, J., Natarajan, A., Morisseau, C., Hammock, B., Chorev, M., Aktas, B. “Explorations of substituted urea functionality for discovery of new activators of the heme regulated inhibitor kinase” J. Med. Chem. 2013, 56, 9457-9470. PMCID: PMC3938169

  66. Chaturvedi, N. K., Rajule, R. N., Shukla, A., Radhakrishnan, P., Todd, G. L., Natarajan, A., Vose, J. M., Joshi S. S. “Novel treatment for mantle cell lymphoma including therapy-resistant tumor by NF-κB and mTOR dual targeting approach” Mol. Cancer Ther. 2013, 12, 2006-2017. PMCID: PMC4124828

  67. Arnst, J. L., Davies, C. W., Raja, S. M., Das, C., Natarajan, A.* “High-throughput compatible FRET-based assay to identify small molecule inhibitors of AMSH deubiquitinase activity” Anal. Biochem. 2013, 440, 71-77. PMCID: PMC3784021

  68. Kumar, E. A., Chen, Q., Kizhake, S., Kolar, C., Kang, M., Chang, C., Borgstahl, G. E. O., Natarajan, A.* “The paradox of conformational constrain in the design of Cbl(TKB)-binding peptides” Sci. Rep. 2013, 3, 1639, DOI: 10.1038/srep01639. PMCID: PMC3965358

  69. Radhakrishnan, P., Bryant, V. C., Blowers, E. B., Rajule, R. N., Gautam, N., Anwar, M. M., Mohr, A. M., Grandgenett, P. A., Bunt, S. K., Arnst, J. L., Lele, S. M., Alnouti, Y., Hollingsworth, M. A., Natarajan, A.* “Targeting the NF-κB and mTOR pathways with a quinoxaline urea analog that inhibits IKKβ for pancreas cancer therapy” Clin. Cancer Res. 2013, 19, 2025-2035. PMCID: PMC3630250

  70. Coote, P., Arthanari, H., Yu, T-Y., Natarajan, A., Wagner, G., Khaneja, N. “Pulse design for broadband correlation NMR spectroscopy by multi-rotating frames” J. Biomol. NMR. 2013, 55, 291-302. PMCID: PMC4344189

  71. Gautam, N., Bathena, S. R., Chen, Q., Natarajan, A., Alnouti, Y. “Pharmacokinetics, protein binding and metabolism of a quinoxaline urea analog as NF-κB inhibitor in mice and rats by LC-MS/MS” Biomed. Chromatogr. 2013, 7, 900-909. PMCID: PMC3760428

  72. Rana, S., Natarajan, A.* “Face selective reduction of the exocyclic double bond in isatin derived spirocyclic lactones” Org. Biomol. Chem. 2013, 11, 244-247. PMCID: PMC3535013

  73. Mohapatra, B., Ahmad, G., Nadeau, S., Zutshi, N., An, W., Scheffe, S., Dong, L., Feng, D., Goetz, B., Arya, P., Bailey, T. A., Palermo, N. Y., Borgstahl, G. E. O., Natarajan, A., Raja, S. M., Naramura, M., Band, V., Band, H. “Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases” Biochim. Biophys. Acta. 2013, 1833, 122-139. PMCID: PMC3628764. 

  74. Pessetto, Z. Y., Yan, Y., Bessho, T., Natarajan, A.* “Inhibition of BRCT(BRCA1)-phosphoprotein interaction enhances the cytotoxic effect of Olaparib in breast cancer cells: A proof of concept study for synthetic lethal therapeutic option” Breast Cancer Res Treat. 2012, 134, 511-517. PMCID: PMC3402595.

  75. Kumar, E. A., Yuan, Z., Palermo, N. Y., Dong, L., Ahmad, G., Lokesh, G. L., Kolar, C., Kizhake, S., Borgstahl, G. E. O., Band, H., Natarajan, A.* “Peptide truncation leads to a twist and an unusual increase in affinity for Cbl tyrosine kinase binding domain” J. Med. Chem. 2012, 55(7), 3583-3587. PMCID: PMC3325325.

  76. Rajule, R., Bryant, V. C., Lopez, H., Luo, X., Natarajan, A.* “Perturbing pro-survival proteins using quinoxaline derivatives: A structure activity relationship study” Bioorg. Med. Chem. 2012, 20(7), 2227-2234. PMCID: PMC3303926.

  77. Bryant, V. C., Kishore Kumar, G. D., Nyong, A. M., Natarajan, A.* “Synthesis and evaluation of macrocyclic diarylether heptanoid natural products and their analogs” Bioorg. Med. Chem. Lett. 2012, 22(1), 245-248. PMCID: PMC3248982.

  78. Nadeau, S., An, W., Palermo, N. Y., Feng, D., Ahmad, G., Dong, L., Borgstahl, G. E. O., Natarajan, A., Naramura, M., Band, V., Band, H. “Oncogenic signaling by leukemia-associated mutant Cbl proteins” Biochem. Anal. Biochem. 2012, S6-001, doi:10.4172/2161-1009.S6-001. PMCID: PMC3757940.

  79. Anisimov, V. M., Ziemys, A., Kizhake, S., Yuan, Z., Natarajan, A.,* Cavasotto, C. N. “Computational and experimental study of protein-ligand interaction between the carboxy terminus domain of BRCA1 and phosphorylated peptides” J. Comput. Aided Mol. Des. 2011, 25(11), 1071-1084. PMCID: PMC3400539.

  80. Yuan, Z., Kumar, E. A., Campbell, S. J., Palermo, N. Y., Kizhake, S., Glover, M. J. N., Natarajan, A.* “Exploiting the P-1 pocket of BRCT domains towards a structure guided inhibitor design” ACS Med. Chem. Lett. 2011, 2(10), 764-767. PMCID: PMC3201719.

  81. Palermo, N. Y., Natarajan, A.* “Beyond the frog: The evolution of homology models of human IKKβ” Bioorg. Med. Chem. Lett. 2011, 21(20), 6081-6084. PMCID: PMC3177977.

  82. Yuan, Z., Kumar, E. A., Kizhake, S., Natarajan, A.* “Structure activity relationship studies to probe the phosphoprotein binding site on the BRCT domains of BRCA1” J. Med. Chem. 2011, 54(12), 4264-4268. PMCID: PMC3117075.

  83. Prakash, A., Natarajan, A., Marky, L. A., Ouellette, A. M. Borgstahl, G. E. O. “Identification of the DNA binding domains of replication protein A that recognize G-quadruplex DNA” J. Nucleic Acids 2011, doi:10.4061/2011/896947. PMCID: PMC3136212.

  84. Naramura, M., Nadeau, S., Mohapatra, B., Ahmad, G., Mukhopadhyay, C., Sattler, M., Raja, S. M., Natarajan, A., Band, V., Band, H. “Mutant Cbl proteins as oncogenic drivers in myeloproliferative disorders” Oncotarget 2011, 2(3), 245-250. PMCID: PMC3134300.

  85. Chen, Q., Bryant, V. C., Lopez, H., Kelly, D. L., Luo, X., Natarajan, A.* “2,3-Substituted quinoxalin-6-amine analogs as antiproliferatives: A structure activity relationship study” Bioorg. Med. Chem. Lett. 2011, 21(7), 1929-1932. PMCID: PMC3063321.

  86. Kumar, E. A., Charvet, C. D., Lokesh, G. L., Natarajan, A.* “High throughput fluorescence polarization assay to identify inhibitors of Cbl(TKB)-PTK interactions” Anal. Biochem. 2011, 411(2), 254-260. PMCID: PMC3078584.

  87. Raja, S. M., Clubb, R., Ortega-Cava, C., Bailey, T., Duan, L., Reddi, A. L., Nyong, A., Natarajan, A., Band, V., Band, H. “Anticancer activity of Celastrol against ErbB2-overexpressing breast cancer: Role of Michael acceptor functionality” Cancer Biology and Therapy 2011, 11(2), 263-276. PMCID: PMC3047084.

  88. Ray, D., Nyong, A. M., Natarajan, A.* “Synthesis of unnatural amino acid derivatives via palladium catalyzed 1,4 addition of boronic acids” Tetrahedron Lett. 2010, 51(19), 2655-2656. PMCID: PMC2895672.

  89. Joseph, P. B. J., Yuan, Z., Kumar, E. A., Lokesh, G. L., Kizhake, S., Rajarathnam, K., Natarajan, A.* “Structural characterization of BRCT-tetrapeptide interaction” Biochem. Biophys. Res. Commun. 2010, 393(2), 207-210. PMCID: PMC2834807.

  90. Reilly, M. T., Cunningham, K. A., Natarajan, A. “Protein-protein interactions as therapeutic targets in neuropsychopharmacology” Neuropsychopharmacology. 2009, 34(1), 247-248. PMID: 19079071.

  91. Kishore Kumar, G. D., Natarajan, A.* “Total Synthesis of Ovalifoliolatin B, Acerogenin A and C” Tetrahedron Lett. 2008, 49(13), 2103-2105. https://doi.org/10.1016/j.tetlet.2008.01.135.

  92. Simeonov, A., Yasgar, A., Jadhav, A., Lokesh, G. L., Klumpp, C., Michael, S., Austin, C. P., Natarajan, A.*, Inglese, J. “Dual-Fluorophore Quantitative High-throughput Screen for Inhibitors of BRCT-Phosphoprotein Interaction” Anal. Biochem. 2008, 375(1), 60-70. PMCID: PMC3389998. 

  93. Lory, P. M. J., Estrella-Jimenez, M. E., Shashack, M. J., Lokesh, G. L., Natarajan, A., Gilbertson, S. R. “Synthesis and screening of 3-substituted thioxanthen-9-one-10,10-dioxides” Bioorg. Med. Chem. Lett. 2007, 17(21), 5940-5943. PMCID: PMC2040121.

  94. Lokesh, G. L., Muralidhara, B. K., Negi, S., Natarajan, A.* “Thermodynamics of phosphopeptide tethering to BRCT: The structural minima for inhibitor design” J. Am. Chem. Soc. 2007, 129(35), 10658-10659. PMID: 17685618.

  95. Kishore Kumar, G. D., Saenz, D., Lokesh, G. L., Natarajan, A.* “Microwave assisted cleavage of phosphate, phosphonate and phosphoramide esters” Tetrahedron Lett. 2006, 47(35), 6281-6284. PMCID: PMC10144917.

  96. Lokesh, G. L., Rachamallu, A., Kishore Kumar, G. D., Natarajan, A.* “High throughput fluorescence polarization assay to identify small molecule inhibitors of BRCT domains of BRCA1” Anal. Biochem. 2006, 352(1), 135-141. PMID: 16500609.

  97. Natarajan, A., Guo, Y., Arthanari, H., Wagner, G., Halperin, J. A., Chorev, M. “Synthetic studies towards Aryl-(4-Aryl-4H-[1,2,4]triazol-3-yl)-amine as Urea Mimetics" J. Org. Chem. 2005, 70(16), 6362-6368. PMCID: PMC3258527. 

  98. Natarajan, A., Guo, Y., Harbinski, F., Fan, Y.–H., Chen, H., Luus, L., Diercks, J., Aktas, H., Chorev, M., Halperin, J. A. “Novel arylsulfonamide-oxindole hybrid as an anticancer agent that Inhibits translation initiation" J. Med. Chem. 2004, 47(21), 4979-4982. PMCID: PMID: 15456240.

  99. Chen, H., Fan, Y.–H., Natarajan, A., Guo, Y., Iyasere, J., Harbinski, F., Luus, L., Christ, W. J., Aktas, H., Halperin, J. A. “Synthesis and Biological evaluation of thiazolidinediones derivatives as inhibitors of Translation Initiation.” Bioorg. Med. Chem. Lett. 2004, 14(21), 5401-5405. PMID: 15454234.

  100. Natarajan, A., Fan, Y.–H., Chen, H., Guo, Y., Iyasere, J., Harbinski, F., Christ, W. J., Aktas, H., Halperin, J. A. “3,3-Diaryl-1,3-dihydro-indol-2-ones as antiproliferatives mediated by translation initiation inhibition.” J. Med. Chem. 2004, 47(8), 1882-1885. PMID: 15055987.

  101. Natarajan, A., Moerke, N., Fan, Y.–H., Chen, H., Christ, W. J., Wagner, G., Halperin, J. A. “Synthesis of fluorescein labeled 7-methylguanosinemonophosphate.” Bioorg. Med. Chem. Lett. 2004, 14(10), 2657-2660. PMID: 15109672.

  102. Fan, Y. –H., Chen, H., Natarajan, A., Guo, Y., Iyasere, J., Harbinski, F., Christ, W. J., Aktas, H., Halperin, J. A. “Structure-Activity Requirements for Depletion of ER Calcium by Troglitazone derivatives.” Bioorg. Med. Chem. Lett. 2004, 14(10), 2547-2550. PMID: 15109648.

  103. Ganorkar, R., Natarajan, A., Mamai, A., Madalengoitia, J. S. “Synthesis of conformationally constrained lysine analogs” J. Org. Chem. 2006, 71(13), 5004-5007. PMID: 16776535.

  104. Zhang, R., Nickl, C. K., Mamai, A., Flemer, S., Natarajan, A., Dostmann, W. R., Madalengoitia, J. S. “Poly-L-proline type II peptide mimics as probes of the active site occupancy requirements of cGMP-dependent protein kinase” J. Peptide Res. 2005, 66(4), 151-159. PMID: 16138853.

  105. Mamai, A., Zhang, R., Natarajan, A., Madalengoitia, J. S.  “Poly-L-proline Type II Peptide Mimics Based on the 3-Azabicyclo[3.1.0]hexane System.” J. Org. Chem. 2001, 66(2), 455-460. PMID: 11429814.

  106. Natarajan, A., Madalengoitia, J. S.  “Molecular diversity approach to the synthesis of peptide-derived ruthenium complexes and their evaluation as oxidation catalysts.” Tetrahedron Lett. 2000, 41(31), 5789-5793. https://doi.org/10.1016/S0040-4039(00)00851-0.

  107. Natarajan, A., Madalengoitia, J. S.  “Optimization of variables for screening solid-supported metal complexes as oxidation catalysts.” Tetrahedron Lett. 2000, 41(31), 5783-5787. https://doi.org/10.1016/S0040-4039(00)00850-9.